Guillermo Ponce de Leon, MD, FACS


Office Locations

Memorial Hermann
Southwest Clinic

7777 Southwest Fwy
Suite 810
Houston, Texas 77074
Phone: 713.772.1200
Fax: 713.772.0258


Methodist Sugar Land Clinic
16651 Southwest Fwy
Suite 360
Sugar Land, Texas 77479
Phone: 713.772.1200
Fax: 281.491.0426


Memorial Hermann
Sugar Land Clinic

17510 W. Grand Parkway S.
Suite 490
Sugar Land, Texas 77479
Phone: 713.772.1200
Fax: 281.342.3957


Dr. Ponce de Leon is a native of Cuba who completed medical school at the University of Texas at Houston. He completed general surgery training at Baylor University Medical Center in Dallas. He is a pioneer in advanced laparoscopic general surgery, recently performing the first single incision adrenalectomy in Texas. He also specializes in bariatric surgery, including lap band. He recently became certified to perform a new robotic surgery called the da Vinci procedure. Dr. Ponce de Leon is a fluent Spanish speaker and stays active in the Hispanic community. In his spare time, he enjoys fishing and spending time with his family.


  • General Surgeon, Southwest Surgical Associates, LLP – July 1998 to present
    • Specialty in General Surgery with expertise in Advanced Laparoscopic Surgery
    • Extensive experience in single-incision laparoscopic surgery
    • Performed 1st single incision laparoscopic adrenalectomy in Texas
    • Certified on the Da Vinci - robotic-assisted surgical technique


  • General Surgery Internship/Residency
    • Baylor University Medical Center, Dallas, Texas, 1993 – 1998
  • Transitional Internship
    • University of Texas at Houston, School of  Medicine,1992 – 1993
  • Doctor of Medicine
    • University of Texas at Houston, School of Medicine,1988-1992
  • Bachelor of Science, Biology & Chemistry
    • Houston Baptist University, Houston, Texas, 1978 – 1982

Academic Appointments

  • Chief of Surgery, Methodist Sugar Land Hospital, 2010-2012
  • Clinical Assistant Professor of Surgery (General)
    • The University of Texas Health Science Center at Houston Medical
  • Chair of the Department of Surgery
    • Methodist Sugar Land Hospital, 2005 to present
  • Chairman of the Department of Surgery
    • Sugar Land Surgical Hospital, 2005 to present
  • Chariman of Peri-operative Committee
    • The Methodist Hospital, Sugar Land
  • Supervises the training of medical Residents and Physicians' Assistants


  • Awarded for Top Score in Surgical In Training Exam During Internship at Baylor

Professional Organizations

  • Fellow, American College of Surgeons
  • American Board of Surgery
  • American Medical Association
  • Texas Medical Association
  • American Society for Metabolic and Bariatric Surgery

Hospital Affliations

  • Memorial Hermann Hospital Southwest
  • Memorial Hermann Hospital Sugar Land
  • The Methodist Hospital Sugar Land
  • St. Luke’s Episcopal Hospital Sugar Land
  • Sugar Land Surgical Hospital
  • Memorial Hermann Memorial City